Title |
Reduced Theta Connectivity during Set-Shifting in Children with Autism
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Published in |
Frontiers in Human Neuroscience, January 2013
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DOI | 10.3389/fnhum.2013.00785 |
Pubmed ID | |
Authors |
Sam M. Doesburg, Julie Vidal, Margot J. Taylor |
Abstract |
Autism spectrum disorder (ASD) is a characterized by deficits in social cognition and executive function. An area of particular difficulty for children with ASD is cognitive flexibility, such as the ability to shift between attentional or response sets. The biological basis of such deficits remains poorly understood, although atypical development of structural and functional brain connectivity have been reported in ASD, suggesting that disruptions of normal patterns of inter-regional communication may contribute to cognitive problems in this group. The present magnetoencephalography study measured inter-regional phase synchronization while children with ASD and typically developing matched controls (6-14 years of age) performed a set-shifting task. Reduced theta-band phase synchronization was observed in children with ASD during extradimensional set-shifting. This reduction in task-dependent inter-regional connectivity encompassed numerous areas including multiple frontal lobe regions, and indicates that problems with communication among brain areas may contribute to difficulties with executive function in ASD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 33% |
France | 1 | 17% |
Ireland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | <1% |
France | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 139 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 19% |
Researcher | 19 | 13% |
Student > Master | 19 | 13% |
Student > Bachelor | 17 | 12% |
Student > Postgraduate | 10 | 7% |
Other | 27 | 19% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 48 | 33% |
Neuroscience | 25 | 17% |
Medicine and Dentistry | 10 | 7% |
Agricultural and Biological Sciences | 9 | 6% |
Engineering | 5 | 3% |
Other | 17 | 12% |
Unknown | 31 | 21% |