Reading into neuronal oscillations in the visual system: implications for developmental dyslexia

Trichur R. Vidyasagar

While phonological impairments are common in developmental dyslexia, there has recently been much debate as to whether there is a causal link between the phonological difficulties and the reading problem. An alternative suggestion has been gaining ground that the core deficit in dyslexia is in visual attentional mechanisms. If so, the visual aetiology may be at any of a number of sites along the afferent magnocellular pathway or in the dorsal cortical stream that are all essential for a visuo-spatial attentional feedback to the primary visual cortex. It has been suggested that the same circuits and pathways of top-down attention used for serial visual search are used for reading. Top-down signals from the dorsal parietal areas to primary visual cortex serially highlight cortical locations representing successive letters in a text before they can be recognized and concatenated into a word. We had shown in non-human primates that the mechanism of such a top-down feedback in a visual attention task uses synchronized neuronal oscillations at the lower end of the gamma frequency range. It is no coincidence that reading graphemes in a text also happens at the low gamma frequencies. The basic proposal here is that each cycle of gamma oscillation focuses an attentional spotlight on the primary visual cortical representation of just one or two letters before sequential recognition of letters and their concatenation into word strings. The timing, period, envelope, amplitude, and phase of the synchronized oscillations modulating the incoming signals in the striate cortex would have a profound influence on the accuracy and speed of reading. Thus, the general temporal sampling difficulties in dyslexic subjects may impact reading not necessarily by causing phonological deficits, but by affecting the spatio-temporal parsing of the visual input within the visual system before these signals are used for letter and word recognition.