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Neural activity in relation to empirically derived personality syndromes in depression using a psychodynamic fMRI paradigm

Overview of attention for article published in Frontiers in Human Neuroscience, January 2013
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Title
Neural activity in relation to empirically derived personality syndromes in depression using a psychodynamic fMRI paradigm
Published in
Frontiers in Human Neuroscience, January 2013
DOI 10.3389/fnhum.2013.00812
Pubmed ID
Authors

Svenja Taubner, Daniel Wiswede, Henrik Kessler

Abstract

Objective: The heterogeneity between patients with depression cannot be captured adequately with existing descriptive systems of diagnosis and neurobiological models of depression. Furthermore, considering the highly individual nature of depression, the application of general stimuli in past research efforts may not capture the essence of the disorder. This study aims to identify subtypes of depression by using empirically derived personality syndromes, and to explore neural correlates of the derived personality syndromes. Materials and Methods: In the present exploratory study, an individually tailored and psychodynamically based functional magnetic resonance imaging paradigm using dysfunctional relationship patterns was presented to 20 chronically depressed patients. Results from the Shedler-Westen Assessment Procedure (SWAP-200) were analyzed by Q-factor analysis to identify clinically relevant subgroups of depression and related brain activation. Results: The principle component analysis of SWAP-200 items from all 20 patients lead to a two-factor solution: "Depressive Personality" and "Emotional-Hostile-Externalizing Personality." Both factors were used in a whole-brain correlational analysis but only the second factor yielded significant positive correlations in four regions: a large cluster in the right orbitofrontal cortex (OFC), the left ventral striatum, a small cluster in the left temporal pole, and another small cluster in the right middle frontal gyrus. Discussion: The degree to which patients with depression score high on the factor "Emotional-Hostile-Externalizing Personality" correlated with relatively higher activity in three key areas involved in emotion processing, evaluation of reward/punishment, negative cognitions, depressive pathology, and social knowledge (OFC, ventral striatum, temporal pole). Results may contribute to an alternative description of neural correlates of depression showing differential brain activation dependent on the extent of specific personality syndromes in depression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Argentina 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 14%
Researcher 8 14%
Student > Master 7 13%
Student > Bachelor 4 7%
Professor 4 7%
Other 10 18%
Unknown 15 27%
Readers by discipline Count As %
Psychology 23 41%
Medicine and Dentistry 4 7%
Neuroscience 4 7%
Business, Management and Accounting 2 4%
Engineering 2 4%
Other 3 5%
Unknown 18 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2015.
All research outputs
#13,901,154
of 22,729,647 outputs
Outputs from Frontiers in Human Neuroscience
#4,299
of 7,134 outputs
Outputs of similar age
#164,428
of 280,769 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#576
of 862 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,134 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,769 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 862 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.