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Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review

Overview of attention for article published in Frontiers in Human Neuroscience, March 2014
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3 X users
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2 Wikipedia pages

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60 Dimensions

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128 Mendeley
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Title
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review
Published in
Frontiers in Human Neuroscience, March 2014
DOI 10.3389/fnhum.2014.00139
Pubmed ID
Authors

Michelle L. Keightley, Katia J. Sinopoli, Karen D. Davis, David J. Mikulis, Richard Wennberg, Maria C. Tartaglia, Jen-Kai Chen, Charles H. Tator

Abstract

While generalized cerebral atrophy and neurodegenerative change following traumatic brain injury (TBI) is well recognized in adults, it remains comparatively understudied in the pediatric population, suggesting that research should address the potential for neurodegenerative change in children and youth following TBI. This focused review examines original research findings documenting evidence for neurodegenerative change following TBI of all severities in children and youth. Our relevant inclusion and exclusion criteria identified a total of 16 articles for review. Taken together, the studies reviewed suggest there is evidence for long-term neurodegenerative change following TBI in children and youth. In particular both cross-sectional and longitudinal studies revealed volume loss in selected brain regions including the hippocampus, amygdala, globus pallidus, thalamus, periventricular white matter, cerebellum, and brain stem as well as overall decreased whole brain volume and increased CSF and ventricular space. Diffusion Tensor Imaging (DTI) studies also report evidence for decreased cellular integrity, particularly in the corpus callosum. Sensitivity of the hippocampus and deep limbic structures in pediatric populations are similar to findings in the adult literature and we consider the data supporting these changes as well as the need to investigate the possibility of neurodegenerative onset in childhood associated with mild traumatic brain injury (mTBI).

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Unknown 125 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 14%
Student > Master 18 14%
Student > Ph. D. Student 17 13%
Student > Bachelor 14 11%
Other 6 5%
Other 24 19%
Unknown 31 24%
Readers by discipline Count As %
Psychology 24 19%
Neuroscience 20 16%
Medicine and Dentistry 15 12%
Agricultural and Biological Sciences 12 9%
Engineering 5 4%
Other 13 10%
Unknown 39 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2020.
All research outputs
#6,029,242
of 22,753,345 outputs
Outputs from Frontiers in Human Neuroscience
#2,460
of 7,138 outputs
Outputs of similar age
#57,173
of 223,393 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#66
of 126 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 7,138 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.