↓ Skip to main content

Assessing the effects of common variation in the FOXP2 gene on human brain structure

Overview of attention for article published in Frontiers in Human Neuroscience, July 2014
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
29 X users

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
76 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Assessing the effects of common variation in the FOXP2 gene on human brain structure
Published in
Frontiers in Human Neuroscience, July 2014
DOI 10.3389/fnhum.2014.00473
Pubmed ID
Authors

Martine Hoogman, Tulio Guadalupe, Marcel P. Zwiers, Patricia Klarenbeek, Clyde Francks, Simon E. Fisher

Abstract

The FOXP2 transcription factor is one of the most well-known genes to have been implicated in developmental speech and language disorders. Rare mutations disrupting the function of this gene have been described in different families and cases. In a large three-generation family carrying a missense mutation, neuroimaging studies revealed significant effects on brain structure and function, most notably in the inferior frontal gyrus, caudate nucleus, and cerebellum. After the identification of rare disruptive FOXP2 variants impacting on brain structure, several reports proposed that common variants at this locus may also have detectable effects on the brain, extending beyond disorder into normal phenotypic variation. These neuroimaging genetics studies used groups of between 14 and 96 participants. The current study assessed effects of common FOXP2 variants on neuroanatomy using voxel-based morphometry (VBM) and volumetric techniques in a sample of >1300 people from the general population. In a first targeted stage we analyzed single nucleotide polymorphisms (SNPs) claimed to have effects in prior smaller studies (rs2253478, rs12533005, rs2396753, rs6980093, rs7784315, rs17137124, rs10230558, rs7782412, rs1456031), beginning with regions proposed in the relevant papers, then assessing impact across the entire brain. In the second gene-wide stage, we tested all common FOXP2 variation, focusing on volumetry of those regions most strongly implicated from analyses of rare disruptive mutations. Despite using a sample that is more than 10 times that used for prior studies of common FOXP2 variation, we found no evidence for effects of SNPs on variability in neuroanatomy in the general population. Thus, the impact of this gene on brain structure may be largely limited to extreme cases of rare disruptive alleles. Alternatively, effects of common variants at this gene exist but are too subtle to be detected with standard volumetric techniques.

X Demographics

X Demographics

The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 3%
United Kingdom 2 3%
Belgium 1 1%
China 1 1%
United States 1 1%
Unknown 69 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Student > Master 13 17%
Researcher 12 16%
Student > Bachelor 6 8%
Professor > Associate Professor 5 7%
Other 13 17%
Unknown 14 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 18%
Agricultural and Biological Sciences 13 17%
Neuroscience 11 14%
Psychology 9 12%
Medicine and Dentistry 6 8%
Other 7 9%
Unknown 16 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2018.
All research outputs
#2,235,120
of 24,688,240 outputs
Outputs from Frontiers in Human Neuroscience
#1,055
of 7,532 outputs
Outputs of similar age
#21,957
of 232,804 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#52
of 253 outputs
Altmetric has tracked 24,688,240 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,532 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,804 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 253 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.