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Modulation of Risky Choices in Recently Abstinent Dependent Cocaine Users: A Transcranial Direct-Current Stimulation Study

Overview of attention for article published in Frontiers in Human Neuroscience, August 2014
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Title
Modulation of Risky Choices in Recently Abstinent Dependent Cocaine Users: A Transcranial Direct-Current Stimulation Study
Published in
Frontiers in Human Neuroscience, August 2014
DOI 10.3389/fnhum.2014.00661
Pubmed ID
Authors

Alessandra Gorini, Claudio Lucchiari, William Russell-Edu, Gabriella Pravettoni

Abstract

Previous neurobiological and neuropsychological investigations have shown that risk-taking behaviors and addictions share many structural and functional aspects. In particular, both are characterized by an irresistible need to obtain immediate rewards and by specific alterations in brain circuits responsible for such behaviors. In this study, we used transcranial direct-current stimulation over the dorsolateral prefrontal cortex (DLPFC) of two samples of subjects (18 dependent cocaine users and 18 control subjects) to investigate the effects of left and right cortical excitability on two risk tasks: (1) the balloon analog risk task (BART) and (2) the game of dice task (GDT). All subjects randomly received a left anodal/right cathodal stimulation (LAn+), a right anodal/left cathodal stimulation (RAn+), and a sham (placebo) stimulation each run at least 48 h apart. Participants were asked to perform the BART and the GDT immediately before and after each stimulation. Our results reveal that the activation of the DLPFC (left and right) results in a reduction of risky behaviors at the BART task both in controls subjects and cocaine dependent users. The effect of tDCS on GDT, instead, is more complex. Cocaine users increased safe behavior after right DLPFC anodal stimulation, while risk-taking behavior increased after left DLPFC anodal stimulation. Control subjects' performance was only affected by the anodal stimulation of the right DLPFC, resulting in an increase of safe bets. These results support the hypothesis that excessive risk propensity in dependent cocaine users might be due to a hypoactivation of the right DLPFC and an unbalance interhemispheric interaction. In conclusion, since risky decision-making seems to be, at least in part, responsible for maintenance and relapse of addiction, we argue that a neuromodulation-based approach could represent a valuable adjunct in the clinical treatment of addiction.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 3 2%
Spain 2 1%
Switzerland 1 <1%
Unknown 140 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 16%
Student > Ph. D. Student 21 14%
Student > Master 17 12%
Student > Bachelor 12 8%
Other 9 6%
Other 30 21%
Unknown 33 23%
Readers by discipline Count As %
Psychology 36 25%
Neuroscience 28 19%
Medicine and Dentistry 13 9%
Agricultural and Biological Sciences 4 3%
Engineering 4 3%
Other 13 9%
Unknown 48 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2014.
All research outputs
#18,375,478
of 22,759,618 outputs
Outputs from Frontiers in Human Neuroscience
#6,058
of 7,138 outputs
Outputs of similar age
#168,399
of 236,469 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#217
of 251 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,138 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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We're also able to compare this research output to 251 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.