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Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication

Overview of attention for article published in Frontiers in Human Neuroscience, April 2015
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Title
Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication
Published in
Frontiers in Human Neuroscience, April 2015
DOI 10.3389/fnhum.2015.00214
Pubmed ID
Authors

Sara B. Festini, Jessica A. Bernard, Youngbin Kwak, Scott Peltier, Nicolaas I. Bohnen, Martijn L. T. M. Müller, Praveen Dayalu, Rachael D. Seidler

Abstract

Although nigrostriatal changes are most commonly affiliated with Parkinson's disease, the role of the cerebellum in Parkinson's has become increasingly apparent. The present study used lobule-based cerebellar resting state functional connectivity to (1) compare cerebellar-whole brain and cerebellar-cerebellar connectivity in Parkinson's patients both ON and OFF L-DOPA medication and controls, and to (2) relate variations in cerebellar connectivity to behavioral performance. Results indicated that, when contrasted to the control group, Parkinson's patients OFF medication had increased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity, whereas Parkinson's patients ON medication had decreased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity. Moreover, analyses relating levels of cerebellar connectivity to behavioral measures demonstrated that, within each group, increased levels of connectivity were most often associated with improved cognitive and motor performance, but there were several instances where increased connectivity was related to poorer performance. Overall, the present study found medication-variant cerebellar connectivity in Parkinson's patients, further demonstrating cerebellar changes associated with Parkinson's disease and the moderating effects of medication.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 1 1%
France 1 1%
Canada 1 1%
Unknown 78 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 18%
Researcher 14 17%
Student > Ph. D. Student 11 13%
Student > Doctoral Student 9 11%
Student > Bachelor 8 10%
Other 10 12%
Unknown 16 19%
Readers by discipline Count As %
Medicine and Dentistry 19 23%
Neuroscience 13 16%
Psychology 13 16%
Agricultural and Biological Sciences 7 8%
Sports and Recreations 4 5%
Other 7 8%
Unknown 20 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2015.
All research outputs
#18,407,102
of 22,800,560 outputs
Outputs from Frontiers in Human Neuroscience
#6,062
of 7,145 outputs
Outputs of similar age
#193,514
of 265,398 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#160
of 182 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,145 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,398 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.