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Mendeley readers
Attention Score in Context
| Title |
Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, November 2016
|
| DOI | 10.3389/fnhum.2016.00540 |
| Pubmed ID | |
| Authors |
Wen Chen, Chunhui Chen, Mingrui Xia, Karen Wu, Chuansheng Chen, Qinghua He, Gui Xue, Wenjing Wang, Yong He, Qi Dong |
| Abstract |
Catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) genes have been found to interactively influence working memory (WM) as well as brain activation during WM tasks. However, whether the two genes have interactive effects on resting-state activities of the brain and whether these spontaneous activations correlate with WM are still unknown. This study included behavioral data from WM tasks and genetic data (COMT rs4680 and BDNF Val66Met) from 417 healthy Chinese adults and resting-state fMRI data from 298 of them. Significant interactive effects of BDNF and COMT were found for WM performance as well as for resting-state regional homogeneity (ReHo) in WM-related brain areas, including the left medial frontal gyrus (lMeFG), left superior frontal gyrus (lSFG), right superior and medial frontal gyrus (rSMFG), right medial orbitofrontal gyrus (rMOFG), right middle frontal gyrus (rMFG), precuneus, bilateral superior temporal gyrus, left superior occipital gyrus, right middle occipital gyrus, and right inferior parietal lobule. Simple effects analyses showed that compared to other genotypes, subjects with COMT-VV/BDNF-VV had higher WM and lower ReHo in all five frontal brain areas. The results supported the hypothesis that COMT and BDNF polymorphisms influence WM performance and spontaneous brain activity (i.e., ReHo). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 18% |
| Student > Bachelor | 11 | 18% |
| Student > Ph. D. Student | 6 | 10% |
| Researcher | 5 | 8% |
| Student > Postgraduate | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 25% |
| Psychology | 14 | 23% |
| Medicine and Dentistry | 5 | 8% |
| Nursing and Health Professions | 4 | 7% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 15 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2016.
All research outputs
#20,346,264
of 22,893,031 outputs
Outputs from Frontiers in Human Neuroscience
#6,551
of 7,173 outputs
Outputs of similar age
#269,097
of 311,552 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#150
of 160 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,173 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,552 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.