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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effective Connectivity within the Mesocorticolimbic System during Resting-State in Cocaine Users
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, November 2016
|
| DOI | 10.3389/fnhum.2016.00563 |
| Pubmed ID | |
| Authors |
Suchismita Ray, Xin Di, Bharat B. Biswal |
| Abstract |
Objective: Although effective connectivity between brain regions has been examined in cocaine users during tasks, no effective connectivity study has been conducted on cocaine users during resting-state. In the present functional magnetic resonance imaging study, we examined effective connectivity in resting-brain, between the brain regions within the mesocorticolimbic dopamine system, implicated in reward and motivated behavior, while the chronic cocaine users and controls took part in a resting-state scan by using a spectral Dynamic causal modeling (spDCM) approach. Method: As part of a study testing cocaine cue reactivity in cocaine users (Ray et al., 2015b), 20 non-treatment seeking cocaine-smoking (abstinent for at least 3 days) and 17 control participants completed a resting state scan and an anatomical scan. A mean voxel-based time series data extracted from four key brain areas (ventral tegmental area, VTA; nucleus accumbens, NAc; hippocampus, medial frontal cortex) within the mesocorticolimbic dopamine system during resting-state from the cocaine and control participants were used as input to the spDCM program to generate spDCM analysis outputs. Results: Compared to the control group, the cocaine group had higher effective connectivity from the VTA to NAc, hippocampus and medial frontal cortex. In contrast, the control group showed a higher effective connectivity from the medial frontal cortex to VTA, from the NAc to medial frontal cortex, and on the hippocampus self-loop. Conclusions: The present study is the first to show that during resting-state in abstaining cocaine users compared to controls, the VTA initiates an enhanced effective connectivity to NAc, hippocampus and medial frontal cortex areas within the mesocorticolimbic dopamine system, the brain's reward system. Future studies of effective connectivity analysis during resting-state may eventually be used to monitor treatment outcome. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 25% |
| Student > Master | 10 | 19% |
| Researcher | 7 | 13% |
| Student > Bachelor | 3 | 6% |
| Professor > Associate Professor | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 23% |
| Psychology | 8 | 15% |
| Agricultural and Biological Sciences | 3 | 6% |
| Mathematics | 2 | 4% |
| Sports and Recreations | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 19 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2016.
All research outputs
#15,390,684
of 22,896,955 outputs
Outputs from Frontiers in Human Neuroscience
#5,277
of 7,174 outputs
Outputs of similar age
#197,344
of 313,003 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#129
of 166 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,174 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,003 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.