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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Contribution of Neuroepigenetics to Huntington’s Disease
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, January 2017
|
| DOI | 10.3389/fnhum.2017.00017 |
| Pubmed ID | |
| Authors |
Laetitia Francelle, Caroline Lotz, Tiago Outeiro, Emmanuel Brouillet, Karine Merienne |
| Abstract |
Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington's disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of epigenetic changes in HD, in the light of recent advances in neuroepigenetics. We particularly discuss studies using genome-wide scale approaches that provide insights into the relationship between epigenetic regulations, gene expression and neuronal activity in normal and diseased neurons, including HD neurons. We propose that cell-type specific techniques and 3D-based methods will advance knowledge of epigenome in the context of brain region vulnerability in neurodegenerative diseases. A better understanding of the mechanisms underlying epigenetic changes and of their consequences in neurodegenerative diseases is required to design therapeutic strategies more effective than current strategies based on histone deacetylase (HDAC) inhibitors. Researches in HD may play a driving role in this process. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 17% |
| Student > Ph. D. Student | 16 | 15% |
| Student > Bachelor | 15 | 14% |
| Researcher | 14 | 13% |
| Student > Doctoral Student | 4 | 4% |
| Other | 9 | 8% |
| Unknown | 32 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 27% |
| Agricultural and Biological Sciences | 17 | 16% |
| Neuroscience | 12 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Medicine and Dentistry | 5 | 5% |
| Other | 6 | 6% |
| Unknown | 34 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2022.
All research outputs
#7,131,716
of 23,292,144 outputs
Outputs from Frontiers in Human Neuroscience
#2,997
of 7,259 outputs
Outputs of similar age
#133,976
of 421,672 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#83
of 180 outputs
Altmetric has tracked 23,292,144 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 7,259 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.