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Attention Score in Context
| Title |
Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, August 2017
|
| DOI | 10.3389/fnhum.2017.00442 |
| Pubmed ID | |
| Authors |
Shun Yao, Yi Zhong, Yuhao Xu, Jiasheng Qin, Ningning Zhang, Xiaolan Zhu, Yuefeng Li |
| Abstract |
Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in depressed patients and evaluated whether it is related to severity. We included three groups of age- and gender-matched participants: 30 patients with mild-moderate depression (MD), 14 patients with major depression disorder (MDD) and 20 control subjects. All participants underwent MR scans with a 3D gradient-echo sequence reconstructing for QSM and performed the 17-item Hamilton Depression Rating Scale (HDRS) test. In MDD, the susceptibility value in the bilateral putamen was significantly increased compared with MD or control subjects. In addition, a significant difference was also observed in the left thalamus in MDD patients compared with controls. However, the susceptibility values did not differ between MD patients and controls. The susceptibility values positively correlated with the severity of depression as indicated by the HDRS scores. Our results provide evidence that brain iron deposition may be associated with depression and may even be a biomarker for investigating the pathophysiological mechanism of depression. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 7 | 16% |
| Student > Master | 7 | 16% |
| Researcher | 6 | 13% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 13 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 27% |
| Medicine and Dentistry | 8 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
| Engineering | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 12 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2023.
All research outputs
#7,665,679
of 24,929,945 outputs
Outputs from Frontiers in Human Neuroscience
#3,049
of 7,585 outputs
Outputs of similar age
#112,316
of 321,302 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#65
of 128 outputs
Altmetric has tracked 24,929,945 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,585 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 128 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.