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ToolConnect: A Functional Connectivity Toolbox for In vitro Networks

Overview of attention for article published in Frontiers in Neuroinformatics, March 2016
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Title
ToolConnect: A Functional Connectivity Toolbox for In vitro Networks
Published in
Frontiers in Neuroinformatics, March 2016
DOI 10.3389/fninf.2016.00013
Pubmed ID
Authors

Vito Paolo Pastore, Daniele Poli, Aleksandar Godjoski, Sergio Martinoia, Paolo Massobrio

Abstract

Nowadays, the use of in vitro reduced models of neuronal networks to investigate the interplay between structural-functional connectivity and the emerging collective dynamics is a widely accepted approach. In this respect, a relevant advance for this kind of studies has been given by the recent introduction of high-density large-scale Micro-Electrode Arrays (MEAs) which have favored the mapping of functional connections and the recordings of the neuronal electrical activity. Although, several toolboxes have been implemented to characterize network dynamics and derive functional links, no specifically dedicated software for the management of huge amount of data and direct estimation of functional connectivity maps has been developed. toolconnect offers the implementation of up to date algorithms and a user-friendly Graphical User Interface (GUI) to analyze recorded data from large scale networks. It has been specifically conceived as a computationally efficient open-source software tailored to infer functional connectivity by analyzing the spike trains acquired from in vitro networks coupled to MEAs. In the current version, toolconnect implements correlation- (cross-correlation, partial-correlation) and information theory (joint entropy, transfer entropy) based core algorithms, as well as useful and practical add-ons to visualize functional connectivity graphs and extract some topological features. In this work, we present the software, its main features and capabilities together with some demonstrative applications on hippocampal recordings.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Researcher 11 14%
Student > Master 10 12%
Student > Bachelor 8 10%
Professor 6 7%
Other 10 12%
Unknown 19 23%
Readers by discipline Count As %
Neuroscience 22 27%
Engineering 14 17%
Agricultural and Biological Sciences 10 12%
Biochemistry, Genetics and Molecular Biology 5 6%
Computer Science 4 5%
Other 4 5%
Unknown 22 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2016.
All research outputs
#20,317,110
of 22,858,915 outputs
Outputs from Frontiers in Neuroinformatics
#679
of 750 outputs
Outputs of similar age
#254,730
of 300,631 outputs
Outputs of similar age from Frontiers in Neuroinformatics
#11
of 12 outputs
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