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Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration

Overview of attention for article published in Frontiers in Neuroscience, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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1 X user
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3 patents

Citations

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77 Dimensions

Readers on

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123 Mendeley
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Title
Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration
Published in
Frontiers in Neuroscience, January 2012
DOI 10.3389/fnins.2012.00048
Pubmed ID
Authors

Eduardo Gascon, Fen-Biao Gao

Abstract

During normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway. In different cells types, the absence of Dicer, a key miRNA processing enzyme, leads to neurodegeneration through cell-autonomous and non-cell-autonomous mechanisms. Loss of certain miRNAs also causes neurodegeneration in some model organisms. On the other hand, miRNA expression is misregulated in patients with different neurodegenerative diseases. Thus, the miRNA pathway appears to be essential in the pathogenesis of several age-dependent neurodegenerative conditions; however, our understanding of the underlying mechanism remains rudimentary. The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 2 2%
India 1 <1%
Unknown 118 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 27%
Researcher 30 24%
Student > Master 16 13%
Student > Bachelor 15 12%
Other 5 4%
Other 14 11%
Unknown 10 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 42%
Biochemistry, Genetics and Molecular Biology 18 15%
Medicine and Dentistry 16 13%
Neuroscience 14 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 7 6%
Unknown 12 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2020.
All research outputs
#5,239,459
of 25,371,288 outputs
Outputs from Frontiers in Neuroscience
#3,987
of 11,537 outputs
Outputs of similar age
#41,226
of 250,083 outputs
Outputs of similar age from Frontiers in Neuroscience
#44
of 154 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.