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The effects of methylphenidate on cognitive performance of healthy male rats

Overview of attention for article published in Frontiers in Neuroscience, January 2013
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Title
The effects of methylphenidate on cognitive performance of healthy male rats
Published in
Frontiers in Neuroscience, January 2013
DOI 10.3389/fnins.2013.00097
Pubmed ID
Authors

Claire L. Rostron, Elise Kaplan, Victoria Gaeta, Rachel Nigriello, Eleanor J. Dommett

Abstract

WE AIMED TO INVESTIGATE THE EFFECTS OF METHYLPHENIDATE (MPH) IN HEALTHY RATS ON TWO DISTINCT RADIAL MAZE TASKS WHICH RELY ON BRAIN STRUCTURES AND NEUROTRANSMITTERS KNOWN TO BE AFFECTED BY MPH: the Random Foraging Non-Delay Task (RFNDT) and the Delayed Spatial Win Shift Task (DSWT). Hooded Lister rats were trained to complete either the RFNDT or the DSWT having received oral treatment of either a vehicle or MPH (3.0 mg/kg and 5.0 mg/kg for RFNDT, 3.0 mg/kg for DSWT). We found no effect of MPH on the RFNDT relative to the control group. However, those treated with 5.0 mg/kg MPH did take significantly longer to reach criterion performance than those treated with the 3.0 mg/kg MPH, suggesting some doses of MPH can have detrimental effects. For the DSWT, if MPH was present in both phases, performance did not differ from when it was absent in both phases. However, when present in only one phase there was an increase in errors made, although this only reached significance for when MPH was present only in the test-phase. These data suggest that MPH may have detrimental effects on task performance and can result in state-dependent effects in healthy individuals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 4%
Switzerland 1 4%
Brazil 1 4%
Unknown 25 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 29%
Student > Master 4 14%
Student > Bachelor 3 11%
Student > Doctoral Student 2 7%
Student > Ph. D. Student 1 4%
Other 2 7%
Unknown 8 29%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Neuroscience 4 14%
Psychology 4 14%
Agricultural and Biological Sciences 3 11%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 1 4%
Unknown 8 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2013.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#6,688
of 11,541 outputs
Outputs of similar age
#177,364
of 289,007 outputs
Outputs of similar age from Frontiers in Neuroscience
#133
of 246 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 246 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.