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A multi-site resting state fMRI study on the amplitude of low frequency fluctuations in schizophrenia

Overview of attention for article published in Frontiers in Neuroscience, January 2013
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Title
A multi-site resting state fMRI study on the amplitude of low frequency fluctuations in schizophrenia
Published in
Frontiers in Neuroscience, January 2013
DOI 10.3389/fnins.2013.00137
Pubmed ID
Authors

Jessica A. Turner, Eswar Damaraju, Theo G. M. van Erp, Daniel H. Mathalon, Judith M. Ford, James Voyvodic, Bryon A. Mueller, Aysenil Belger, Juan Bustillo, Sarah McEwen, Steven G. Potkin, FBIRN, Vince D. Calhoun

Abstract

Background: This multi-site study compares resting state fMRI amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) between patients with schizophrenia (SZ) and healthy controls (HC). Methods: Eyes-closed resting fMRI scans (5:38 min; n = 306, 146 SZ) were collected from 6 Siemens 3T scanners and one GE 3T scanner. Imaging data were pre-processed using an SPM pipeline. Power in the low frequency band (0.01-0.08 Hz) was calculated both for the original pre-processed data as well as for the pre-processed data after regressing out the six rigid-body motion parameters, mean white matter (WM) and cerebral spinal fluid (CSF) signals. Both original and regressed ALFF and fALFF measures were modeled with site, diagnosis, age, and diagnosis × age interactions. Results: Regressing out motion and non-gray matter signals significantly decreased fALFF throughout the brain as well as ALFF in the cortical edge, but significantly increased ALFF in subcortical regions. Regression had little effect on site, age, and diagnosis effects on ALFF, other than to reduce diagnosis effects in subcortical regions. There were significant effects of site across the brain in all the analyses, largely due to vendor differences. HC showed greater ALFF in the occipital, posterior parietal, and superior temporal lobe, while SZ showed smaller clusters of greater ALFF in the frontal and temporal/insular regions as well as in the caudate, putamen, and hippocampus. HC showed greater fALFF compared with SZ in all regions, though subcortical differences were only significant for original fALFF. Conclusions: SZ show greater eyes-closed resting state low frequency power in frontal cortex, and less power in posterior lobes than do HC; fALFF, however, is lower in SZ than HC throughout the cortex. These effects are robust to multi-site variability. Regressing out physiological noise signals significantly affects both total and fALFF measures, but does not affect the pattern of case/control differences.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
Japan 1 <1%
Canada 1 <1%
Unknown 152 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 23%
Researcher 29 18%
Student > Master 23 15%
Student > Doctoral Student 13 8%
Professor 9 6%
Other 26 16%
Unknown 21 13%
Readers by discipline Count As %
Psychology 33 21%
Neuroscience 32 20%
Engineering 22 14%
Medicine and Dentistry 14 9%
Computer Science 6 4%
Other 14 9%
Unknown 37 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2013.
All research outputs
#17,283,763
of 25,371,288 outputs
Outputs from Frontiers in Neuroscience
#8,065
of 11,537 outputs
Outputs of similar age
#193,607
of 288,991 outputs
Outputs of similar age from Frontiers in Neuroscience
#158
of 246 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 246 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.