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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging
|
|---|---|
| Published in |
Frontiers in Neuroscience, January 2013
|
| DOI | 10.3389/fnins.2013.00145 |
| Pubmed ID | |
| Authors |
Elias Gebara, Sebastien Sultan, Jacqueline Kocher-Braissant, Nicolas Toni |
| Abstract |
Adult hippocampal neurogenesis results in the formation of new neurons and is a process of brain plasticity involved in learning and memory. The proliferation of adult neural stem or progenitor cells is regulated by several extrinsic factors such as experience, disease or aging and intrinsic factors originating from the neurogenic niche. Microglia is very abundant in the dentate gyrus (DG) and increasing evidence indicates that these cells mediate the inflammation-induced reduction in neurogenesis. However, the role of microglia in neurogenesis in physiological conditions remains poorly understood. In this study, we monitored microglia and the proliferation of adult hippocampal stem/progenitor cells in physiological conditions known to increase or decrease adult neurogenesis, voluntary running and aging respectively. We found that the number of microglia in the DG was strongly inversely correlated with the number of stem/progenitor cells and cell proliferation in the granule cell layer. Accordingly, co-cultures of decreasing neural progenitor/glia ratio showed that microglia but not astroglia reduced the number of progenitor cells. Together, these results suggest that microglia inhibits the proliferation of neural stem/progenitor cells despite the absence of inflammatory stimulus. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Japan | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 133 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 21% |
| Student > Bachelor | 23 | 17% |
| Researcher | 23 | 17% |
| Student > Master | 17 | 12% |
| Student > Postgraduate | 10 | 7% |
| Other | 24 | 18% |
| Unknown | 11 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 45 | 33% |
| Agricultural and Biological Sciences | 37 | 27% |
| Medicine and Dentistry | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Psychology | 5 | 4% |
| Other | 13 | 9% |
| Unknown | 14 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#8,261,756
of 25,371,288 outputs
Outputs from Frontiers in Neuroscience
#5,239
of 11,538 outputs
Outputs of similar age
#84,495
of 288,986 outputs
Outputs of similar age from Frontiers in Neuroscience
#108
of 246 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 11,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,986 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 246 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.