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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The FMRP regulon: from targets to disease convergence
|
|---|---|
| Published in |
Frontiers in Neuroscience, January 2013
|
| DOI | 10.3389/fnins.2013.00191 |
| Pubmed ID | |
| Authors |
Esperanza Fernández, Nicholas Rajan, Claudia Bagni |
| Abstract |
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of this protein. Hundreds of potential FMRP mRNA targets and several interacting proteins have been identified. Here, we report the identification of FMRP mRNA targets in the mammalian brain that support the key role of this protein during brain development and in regulating synaptic plasticity. We compared the genes from databases and genome-wide association studies with the brain FMRP transcriptome, and identified several FMRP mRNA targets associated with autism spectrum disorders, mood disorders and schizophrenia, showing a potential common pathway/s for these apparently different disorders. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| Sweden | 1 | 11% |
| Canada | 1 | 11% |
| Mexico | 1 | 11% |
| Switzerland | 1 | 11% |
| Ireland | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 189 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 28% |
| Researcher | 28 | 15% |
| Student > Bachelor | 25 | 13% |
| Student > Master | 23 | 12% |
| Student > Doctoral Student | 10 | 5% |
| Other | 31 | 16% |
| Unknown | 21 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 33% |
| Biochemistry, Genetics and Molecular Biology | 36 | 19% |
| Neuroscience | 36 | 19% |
| Medicine and Dentistry | 16 | 8% |
| Psychology | 6 | 3% |
| Other | 9 | 5% |
| Unknown | 26 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2018.
All research outputs
#7,215,409
of 25,654,806 outputs
Outputs from Frontiers in Neuroscience
#4,672
of 11,659 outputs
Outputs of similar age
#70,975
of 290,396 outputs
Outputs of similar age from Frontiers in Neuroscience
#100
of 246 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 11,659 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 246 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.