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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons
|
|---|---|
| Published in |
Frontiers in Neuroscience, January 2014
|
| DOI | 10.3389/fnins.2014.00016 |
| Pubmed ID | |
| Authors |
John W. Cave, Meng Wang, Harriet Baker |
| Abstract |
Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson's Disease (PD). The use of fetal tissue is not practical for widespread clinical implementation of this therapy, but stem cells are a promising alternative source for obtaining replacement cells. The ideal stem cell source has yet to be established and, in this review, we discuss the potential of neural stem cells in the adult subventricular zone (SVZ) as an autologous source of replacement cells. We identify three key challenges for further developing this potential source of replacement cells: (1) improving survival of transplanted cells, (2) suppressing glial progenitor proliferation and survival, and (3) developing methods to efficiently produce dopaminergic neurons. Subventricular neural stem cells naturally produce a dopaminergic interneuron phenotype that has an apparent lack of vulnerability to PD-mediated degeneration. We also discuss whether olfactory bulb dopaminergic neurons derived from adult SVZ neural stem cells are a suitable source for cell replacement strategies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Arab Emirates | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Australia | 1 | 1% |
| France | 1 | 1% |
| China | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 71 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 27% |
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Student > Doctoral Student | 5 | 6% |
| Other | 10 | 13% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 43% |
| Neuroscience | 12 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Engineering | 3 | 4% |
| Materials Science | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2014.
All research outputs
#17,236,655
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#7,938
of 11,541 outputs
Outputs of similar age
#202,127
of 319,280 outputs
Outputs of similar age from Frontiers in Neuroscience
#33
of 51 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.