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Notching up neural stem cell homogeneity in homeostasis and disease

Overview of attention for article published in Frontiers in Neuroscience, January 2014
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Title
Notching up neural stem cell homogeneity in homeostasis and disease
Published in
Frontiers in Neuroscience, January 2014
DOI 10.3389/fnins.2014.00032
Pubmed ID
Authors

Claudio Giachino, Verdon Taylor

Abstract

Adult neural stem cells (NSCs) are perceived as a homogeneous population of cells that divide infrequently and are capable of multi-lineage differentiation. However, recent data revealed that independent stem cell lineages act in parallel to maintain neurogenesis and provide a cellular source for tissue repair. In addition, even within the same lineage, the stem and progenitor cells are strikingly heterogeneous including NSCs that are dormant or mitotically active. We will discuss these different NSC populations and activity states with relation to their role in neurogenesis and regeneration but also how these different stem cells respond to aging. NSCs depend on Notch signaling for their maintenance. While Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to adult NSC heterogeneity. Understanding the fate of multiple NSC populations with distinct functions has implications for the mechanisms of aging and regeneration.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Sweden 1 1%
Russia 1 1%
United States 1 1%
Poland 1 1%
Unknown 81 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 24%
Researcher 18 21%
Student > Master 11 13%
Student > Postgraduate 7 8%
Student > Bachelor 5 6%
Other 13 15%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 43%
Neuroscience 14 16%
Biochemistry, Genetics and Molecular Biology 12 14%
Medicine and Dentistry 4 5%
Psychology 2 2%
Other 4 5%
Unknown 13 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2014.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#8,670
of 11,541 outputs
Outputs of similar age
#233,957
of 319,280 outputs
Outputs of similar age from Frontiers in Neuroscience
#39
of 51 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.