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X Demographics
Mendeley readers
Attention Score in Context
| Title |
New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
|
|---|---|
| Published in |
Frontiers in Neuroscience, June 2014
|
| DOI | 10.3389/fnins.2014.00142 |
| Pubmed ID | |
| Authors |
Maria F. Eiriz, Jorge Valero, João O. Malva, Liliana Bernardino |
| Abstract |
The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF) upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB). This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 5% |
| Unknown | 35 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 24% |
| Student > Bachelor | 8 | 22% |
| Student > Ph. D. Student | 4 | 11% |
| Researcher | 3 | 8% |
| Other | 2 | 5% |
| Other | 6 | 16% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 32% |
| Agricultural and Biological Sciences | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Medicine and Dentistry | 3 | 8% |
| Immunology and Microbiology | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#9,458
of 11,541 outputs
Outputs of similar age
#167,981
of 229,451 outputs
Outputs of similar age from Frontiers in Neuroscience
#97
of 124 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,451 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.