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The role of GABA in the regulation of GnRH neurons

Overview of attention for article published in Frontiers in Neuroscience, November 2014
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Title
The role of GABA in the regulation of GnRH neurons
Published in
Frontiers in Neuroscience, November 2014
DOI 10.3389/fnins.2014.00387
Pubmed ID
Authors

Miho Watanabe, Atsuo Fukuda, Junichi Nabekura

Abstract

Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for the central regulation of reproduction. Gamma-amino butyric acid (GABA) has long been implicated as one of the major players in the regulation of GnRH neurons. Although GABA is typically an inhibitory neurotransmitter in the mature adult central nervous system, most mature GnRH neurons show the unusual characteristic of being excited by GABA. While many reports have provided much insight into the contribution of GABA to the activity of GnRH neurons, the precise physiological role of the excitatory action of GABA on GnRH neurons remains elusive. This brief review presents the current knowledge of the role of GABA signaling in GnRH neuronal activity. We also discuss the modulation of GABA signaling by neurotransmitters and neuromodulators and the functional consequence of GABAergic inputs to GnRH neurons in both the physiology and pathology of reproduction.

X Demographics

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
Spain 1 <1%
Germany 1 <1%
Unknown 112 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 22%
Student > Master 17 15%
Researcher 14 12%
Student > Bachelor 11 9%
Professor > Associate Professor 8 7%
Other 18 15%
Unknown 23 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 26%
Neuroscience 18 15%
Biochemistry, Genetics and Molecular Biology 16 14%
Medicine and Dentistry 10 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 8 7%
Unknown 29 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2014.
All research outputs
#14,473,281
of 25,373,627 outputs
Outputs from Frontiers in Neuroscience
#5,775
of 11,538 outputs
Outputs of similar age
#183,285
of 369,437 outputs
Outputs of similar age from Frontiers in Neuroscience
#72
of 118 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,437 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.