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Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

Overview of attention for article published in Frontiers in Neuroscience, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
1 news outlet
twitter
18 X users
facebook
2 Facebook pages
googleplus
1 Google+ user
video
1 YouTube creator

Readers on

mendeley
235 Mendeley
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Title
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress
Published in
Frontiers in Neuroscience, January 2015
DOI 10.3389/fnins.2014.00456
Pubmed ID
Authors

Jereme G. Spiers, Hsiao-Jou Cortina Chen, Conrad Sernia, Nickolas A. Lavidis

Abstract

Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Canada 2 <1%
Italy 1 <1%
Romania 1 <1%
Singapore 1 <1%
Unknown 228 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 14%
Student > Bachelor 30 13%
Student > Master 29 12%
Researcher 22 9%
Student > Doctoral Student 13 6%
Other 41 17%
Unknown 68 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 19%
Medicine and Dentistry 30 13%
Biochemistry, Genetics and Molecular Biology 29 12%
Neuroscience 13 6%
Nursing and Health Professions 11 5%
Other 26 11%
Unknown 82 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2022.
All research outputs
#1,518,890
of 25,654,806 outputs
Outputs from Frontiers in Neuroscience
#723
of 11,659 outputs
Outputs of similar age
#20,293
of 361,669 outputs
Outputs of similar age from Frontiers in Neuroscience
#13
of 127 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,659 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,669 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.