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Non-cell autonomous and non-catalytic activities of ATX in the developing brain

Overview of attention for article published in Frontiers in Neuroscience, March 2015
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Title
Non-cell autonomous and non-catalytic activities of ATX in the developing brain
Published in
Frontiers in Neuroscience, March 2015
DOI 10.3389/fnins.2015.00053
Pubmed ID
Authors

Raanan Greenman, Anna Gorelik, Tamar Sapir, Jan Baumgart, Vanessa Zamor, Michal Segal-Salto, Smadar Levin-Zaidman, Vassilis Aidinis, Junken Aoki, Robert Nitsch, Johannes Vogt, Orly Reiner

Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
France 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 29%
Student > Ph. D. Student 8 23%
Professor > Associate Professor 3 9%
Student > Bachelor 2 6%
Other 2 6%
Other 4 11%
Unknown 6 17%
Readers by discipline Count As %
Neuroscience 8 23%
Agricultural and Biological Sciences 8 23%
Biochemistry, Genetics and Molecular Biology 5 14%
Medicine and Dentistry 3 9%
Business, Management and Accounting 1 3%
Other 1 3%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2015.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#8,067
of 11,541 outputs
Outputs of similar age
#164,986
of 272,753 outputs
Outputs of similar age from Frontiers in Neuroscience
#92
of 129 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,753 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.