Title |
Neuronal polarization in the developing cerebral cortex
|
---|---|
Published in |
Frontiers in Neuroscience, April 2015
|
DOI | 10.3389/fnins.2015.00116 |
Pubmed ID | |
Authors |
Akira Sakakibara, Yumiko Hatanaka |
Abstract |
Cortical neurons consist of excitatory projection neurons and inhibitory GABAergic interneurons, whose connections construct highly organized neuronal circuits that control higher order information processing. Recent progress in live imaging has allowed us to examine how these neurons differentiate during development in vivo or in in vivo-like conditions. These analyses have revealed how the initial steps of polarization, in which neurons establish an axon, occur. Interestingly, both excitatory and inhibitory cortical neurons establish neuronal polarity de novo by undergoing a multipolar stage reminiscent of the manner in which polarity formation occurs in hippocampal neurons in dissociated culture. In this review, we focus on polarity formation in cortical neurons and describe their typical morphology and dynamic behavior during the polarization period. We also discuss cellular and molecular mechanisms underlying polarization, with reference to polarity formation in dissociated hippocampal neurons in vitro. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Spain | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Unknown | 124 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 26% |
Researcher | 27 | 21% |
Student > Bachelor | 15 | 12% |
Student > Doctoral Student | 12 | 9% |
Student > Master | 12 | 9% |
Other | 14 | 11% |
Unknown | 16 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 49 | 38% |
Neuroscience | 36 | 28% |
Biochemistry, Genetics and Molecular Biology | 11 | 8% |
Medicine and Dentistry | 3 | 2% |
Computer Science | 1 | <1% |
Other | 5 | 4% |
Unknown | 25 | 19% |