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Transcranial random noise stimulation-induced plasticity is NMDA-receptor independent but sodium-channel blocker and benzodiazepines sensitive

Overview of attention for article published in Frontiers in Neuroscience, April 2015
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Title
Transcranial random noise stimulation-induced plasticity is NMDA-receptor independent but sodium-channel blocker and benzodiazepines sensitive
Published in
Frontiers in Neuroscience, April 2015
DOI 10.3389/fnins.2015.00125
Pubmed ID
Authors

Leila Chaieb, Andrea Antal, Walter Paulus

Abstract

Application of transcranial random noise stimulation (tRNS) between 0.1 and 640 Hz of the primary motor cortex (M1) for 10 min induces a persistent excitability increase lasting for at least 60 min. However, the mechanism of tRNS-induced cortical excitability alterations is not yet fully understood. The main aim of this study was to get first efficacy data with regard to the possible neuronal effect of tRNS. Single-pulse transcranial magnetic stimulation (TMS) was used to measure levels of cortical excitability before and after combined application of tRNS at an intensity of 1 mA for 10 min stimulation duration and a pharmacological agent (or sham) on eight healthy male participants. The sodium channel blocker carbamazepine showed a tendency toward inhibiting MEPs 5-60 min poststimulation. The GABA A agonist lorazepam suppressed tRNS-induced cortical excitability increases at 0-20 and 60 min time points. The partial NMDA receptor agonist D-cycloserine, the NMDA receptor antagonist dextromethorphan and the D2/D3 receptor agonist ropinirole had no significant effects on the excitability increases seen with tRNS. In contrast to transcranial direct current stimulation (tDCS), aftereffects of tRNS are seem to be not NMDA receptor dependent and can be suppressed by benzodiazepines suggesting that tDCS and tRNS depend upon different mechanisms.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
United Kingdom 1 <1%
Sweden 1 <1%
Germany 1 <1%
Unknown 127 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 24%
Student > Master 21 16%
Researcher 19 15%
Student > Bachelor 11 8%
Professor 5 4%
Other 20 15%
Unknown 23 18%
Readers by discipline Count As %
Psychology 34 26%
Neuroscience 27 21%
Medicine and Dentistry 19 15%
Engineering 5 4%
Agricultural and Biological Sciences 4 3%
Other 6 5%
Unknown 36 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2015.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Frontiers in Neuroscience
#9,457
of 11,542 outputs
Outputs of similar age
#207,162
of 278,954 outputs
Outputs of similar age from Frontiers in Neuroscience
#110
of 127 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.