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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
|
|---|---|
| Published in |
Frontiers in Neuroscience, January 2016
|
| DOI | 10.3389/fnins.2016.00012 |
| Pubmed ID | |
| Authors |
Timothy J. Collier, D. Eugene Redmond, Kathy Steece-Collier, Jack W. Lipton, Fredric P. Manfredsson |
| Abstract |
Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson's disease (PD), leading to the proposal that PD is a toxic gain-of-function synucleinopathy. Here we discuss the alternative viewpoint that α-syn displacement from synapses by misfolding and aggregation results in a toxic loss-of-function. In support of this hypothesis we provide evidence from our pilot study demonstrating that knockdown of endogenous α-syn in dopamine neurons of non-human primates reproduces the pattern of nigrostriatal degeneration characteristic of PD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 2 | 40% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 150 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 26% |
| Student > Bachelor | 24 | 16% |
| Researcher | 19 | 13% |
| Student > Master | 17 | 11% |
| Student > Postgraduate | 7 | 5% |
| Other | 15 | 10% |
| Unknown | 29 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 33 | 22% |
| Biochemistry, Genetics and Molecular Biology | 27 | 18% |
| Agricultural and Biological Sciences | 22 | 15% |
| Medicine and Dentistry | 8 | 5% |
| Chemistry | 7 | 5% |
| Other | 18 | 12% |
| Unknown | 35 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2023.
All research outputs
#2,733,705
of 25,460,914 outputs
Outputs from Frontiers in Neuroscience
#1,731
of 11,570 outputs
Outputs of similar age
#46,006
of 405,785 outputs
Outputs of similar age from Frontiers in Neuroscience
#25
of 171 outputs
Altmetric has tracked 25,460,914 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,570 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,785 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.