Title |
Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles
|
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Published in |
Frontiers in Neuroscience, February 2016
|
DOI | 10.3389/fnins.2016.00026 |
Pubmed ID | |
Authors |
Marçal Vilar, Helena Mira |
Abstract |
The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in adult neurogenesis appear to be a common hallmark of different neurodegenerative diseases, understanding the molecular mechanisms controlling adult neurogenesis is a focus of active research. Neurotrophic factors are a family of molecules that play critical roles in the survival and differentiation of neurons during development and in the control of neural plasticity in the adult. Several neurotrophins and neurotrophin receptors have been implicated in the regulation of adult neurogenesis at different levels. Here, we review the current understanding of neurotrophin modulation of adult neurogenesis in both the SVZ and SGZ. We compile data supporting a variety of roles for neurotrophins/neurotrophin receptors in different scenarios, including both expected and unexpected functions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 215 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 18% |
Student > Bachelor | 34 | 16% |
Student > Master | 29 | 13% |
Researcher | 27 | 12% |
Student > Doctoral Student | 9 | 4% |
Other | 24 | 11% |
Unknown | 55 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 52 | 24% |
Biochemistry, Genetics and Molecular Biology | 35 | 16% |
Agricultural and Biological Sciences | 30 | 14% |
Medicine and Dentistry | 15 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 19 | 9% |
Unknown | 59 | 27% |