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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Extracellular Vesicles and a Novel Form of Communication in the Brain
|
|---|---|
| Published in |
Frontiers in Neuroscience, March 2016
|
| DOI | 10.3389/fnins.2016.00127 |
| Pubmed ID | |
| Authors |
Manuela Basso, Valentina Bonetto |
| Abstract |
In numerous neurodegenerative diseases, the interplay between neurons and glia modulates the outcome and progression of pathology. One particularly intriguing mode of interaction between neurons, astrocytes, microglia, and oligodendrocytes is characterized by the release of extracellular vesicles that transport proteins, lipids, and nucleotides from one cell to another. Notably, several proteins that cause disease, including the prion protein and mutant SOD1, have been detected in glia-derived extracellular vesicles and observed to fuse with neurons and trigger pathology in vitro. Here we review the structural and functional characterization of such extracellular vesicles in neuron-glia interactions. Furthermore, we discuss possible mechanisms of extracellular vesicle biogenesis and release from activated glia and microglia, and their effects on neurons. Given that exosomes, the smallest type of extracellular vesicles, have been reported to recognize specific cellular populations and act as carriers of very specialized cargo, a thorough analysis of these vesicles may aid in their engineering in vitro and targeted delivery in vivo, opening opportunities for therapeutics. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 18% |
| Spain | 1 | 6% |
| United Kingdom | 1 | 6% |
| Switzerland | 1 | 6% |
| Unknown | 11 | 65% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 308 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| France | 2 | <1% |
| Brazil | 1 | <1% |
| Mexico | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 300 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 20% |
| Researcher | 55 | 18% |
| Student > Master | 44 | 14% |
| Student > Bachelor | 26 | 8% |
| Student > Doctoral Student | 15 | 5% |
| Other | 43 | 14% |
| Unknown | 64 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 69 | 22% |
| Neuroscience | 58 | 19% |
| Agricultural and Biological Sciences | 56 | 18% |
| Medicine and Dentistry | 18 | 6% |
| Immunology and Microbiology | 7 | 2% |
| Other | 26 | 8% |
| Unknown | 74 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2022.
All research outputs
#2,035,659
of 25,483,400 outputs
Outputs from Frontiers in Neuroscience
#1,132
of 11,581 outputs
Outputs of similar age
#32,898
of 315,556 outputs
Outputs of similar age from Frontiers in Neuroscience
#16
of 177 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,581 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,556 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 177 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.