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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms
|
|---|---|
| Published in |
Frontiers in Neuroscience, May 2016
|
| DOI | 10.3389/fnins.2016.00178 |
| Pubmed ID | |
| Authors |
Carolyn Hollands, Nancy Bartolotti, Orly Lazarov |
| Abstract |
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity. Along with older mature neurons, new neurons structure the dentate gyrus, and determine its function. Recent data suggest that the level of hippocampal neurogenesis is substantial in the human brain, suggesting that neurogenesis may have important implications for human cognition. In support of that, impaired neurogenesis compromises hippocampal function and plays a role in cognitive deficits in Alzheimer's disease mouse models. We review current work suggesting that neuronal differentiation is defective in Alzheimer's disease, leading to dysfunction of the dentate gyrus. Additionally, alterations in critical signals regulating neurogenesis, such as presenilin-1, Notch 1, soluble amyloid precursor protein, CREB, and β-catenin underlie dysfunctional neurogenesis in Alzheimer's disease. Lastly, we discuss the detectability of neurogenesis in the live mouse and human brain, as well as the therapeutic implications of enhancing neurogenesis for the treatment of cognitive deficits and Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 25% |
| Canada | 1 | 25% |
| Chile | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 271 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 58 | 21% |
| Student > Ph. D. Student | 49 | 18% |
| Student > Master | 38 | 14% |
| Researcher | 25 | 9% |
| Student > Doctoral Student | 14 | 5% |
| Other | 41 | 15% |
| Unknown | 48 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 69 | 25% |
| Agricultural and Biological Sciences | 42 | 15% |
| Biochemistry, Genetics and Molecular Biology | 32 | 12% |
| Psychology | 18 | 7% |
| Medicine and Dentistry | 16 | 6% |
| Other | 30 | 11% |
| Unknown | 66 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2021.
All research outputs
#2,450,361
of 25,374,647 outputs
Outputs from Frontiers in Neuroscience
#1,470
of 11,542 outputs
Outputs of similar age
#38,353
of 312,398 outputs
Outputs of similar age from Frontiers in Neuroscience
#22
of 169 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,398 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.