Title |
New Insights in Anorexia Nervosa
|
---|---|
Published in |
Frontiers in Neuroscience, June 2016
|
DOI | 10.3389/fnins.2016.00256 |
Pubmed ID | |
Authors |
Philip Gorwood, Corinne Blanchet-Collet, Nicolas Chartrel, Jeanne Duclos, Pierre Dechelotte, Mouna Hanachi, Serguei Fetissov, Nathalie Godart, Jean-Claude Melchior, Nicolas Ramoz, Carole Rovere-Jovene, Virginie Tolle, Odile Viltart, Jacques Epelbaum |
Abstract |
Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body weight is associated with an intense fear of gaining weight and distorted cognitions regarding weight, shape, and drive for thinness. This article reviews recent evidences from physiology, genetics, epigenetics, and brain imaging which allow to consider AN as an abnormality of reward pathways or an attempt to preserve mental homeostasis. Special emphasis is put on ghrelino-resistance and the importance of orexigenic peptides of the lateral hypothalamus, the gut microbiota and a dysimmune disorder of neuropeptide signaling. Physiological processes, secondary to underlying, and premorbid vulnerability factors-the "pondero-nutritional-feeding basements"- are also discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 32% |
United Kingdom | 2 | 11% |
Australia | 2 | 11% |
Japan | 1 | 5% |
Spain | 1 | 5% |
Switzerland | 1 | 5% |
Unknown | 6 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 16 | 84% |
Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Scientists | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Unknown | 341 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 61 | 18% |
Student > Master | 43 | 13% |
Researcher | 37 | 11% |
Student > Ph. D. Student | 36 | 11% |
Student > Postgraduate | 23 | 7% |
Other | 60 | 18% |
Unknown | 82 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 14% |
Psychology | 41 | 12% |
Neuroscience | 38 | 11% |
Nursing and Health Professions | 34 | 10% |
Agricultural and Biological Sciences | 24 | 7% |
Other | 54 | 16% |
Unknown | 102 | 30% |