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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy
|
|---|---|
| Published in |
Frontiers in Neuroscience, June 2016
|
| DOI | 10.3389/fnins.2016.00294 |
| Pubmed ID | |
| Authors |
José Marco-Contelles, Mercedes Unzeta, Irene Bolea, Gerard Esteban, Rona R. Ramsay, Alejandro Romero, Ricard Martínez-Murillo, M. Carmo Carreiras, Lhassane Ismaili |
| Abstract |
ASS2324 is a hybrid compound resulting from the juxtaposition of donepezil and the propargylamine PF9601N ASS2324 is a multi-target directed propargylamine able to bind to all the AChE/BuChE and MAO A/B enzymesASS2324 shows antioxidant, neuroprotective and suitable permeability propertiesASS2324 restores the scopolamine-induced cognitive impairment to the same extent as donepezil, and is less toxicASS2324 prevents β-amyloid induced aggregation in the cortex of double transgenic miceASS2324 is the most advanced anti-Alzheimer agent for pre-clinical studies that we have identified in our laboratories The complex nature of Alzheimer's disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. In this context, we have designed a number of MTD propargylamines (MTDP) showing antioxidant, anti-beta-amyloid, anti-inflammatory, as well as cholinesterase and monoamine oxidase (MAO) inhibition capacities. Here, we describe these properties in the MTDL ASS234, our lead-compound ready to enter in pre-clinical studies for AD, as a new multipotent, permeable cholinesterase/monoamine oxidase inhibitor, able to inhibit Aβ-aggregation, and possessing antioxidant and neuroprotective properties. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 20% |
| Student > Ph. D. Student | 12 | 15% |
| Student > Bachelor | 9 | 11% |
| Professor > Associate Professor | 7 | 9% |
| Student > Doctoral Student | 3 | 4% |
| Other | 11 | 13% |
| Unknown | 24 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 20 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Neuroscience | 3 | 4% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 13 | 16% |
| Unknown | 29 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2019.
All research outputs
#2,723,924
of 25,394,764 outputs
Outputs from Frontiers in Neuroscience
#1,712
of 11,544 outputs
Outputs of similar age
#47,289
of 367,120 outputs
Outputs of similar age from Frontiers in Neuroscience
#32
of 156 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,120 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.