Title |
Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche
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Published in |
Frontiers in Neuroscience, August 2016
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DOI | 10.3389/fnins.2016.00332 |
Pubmed ID | |
Authors |
Eun Hyuk Chang, Istvan Adorjan, Mayara V. Mundim, Bin Sun, Maria L. V. Dizon, Francis G. Szele |
Abstract |
Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 101 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 24% |
Student > Bachelor | 16 | 16% |
Student > Master | 14 | 14% |
Researcher | 10 | 10% |
Student > Postgraduate | 6 | 6% |
Other | 12 | 12% |
Unknown | 19 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 28 | 28% |
Biochemistry, Genetics and Molecular Biology | 18 | 18% |
Medicine and Dentistry | 15 | 15% |
Agricultural and Biological Sciences | 10 | 10% |
Psychology | 2 | 2% |
Other | 4 | 4% |
Unknown | 24 | 24% |