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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis
|
|---|---|
| Published in |
Frontiers in Neuroscience, July 2016
|
| DOI | 10.3389/fnins.2016.00340 |
| Pubmed ID | |
| Authors |
Fotis Tsetsos, Shanmukha S. Padmanabhuni, John Alexander, Iordanis Karagiannidis, Margaritis Tsifintaris, Apostolia Topaloudi, Dimitrios Mantzaris, Marianthi Georgitsi, Petros Drineas, Peristera Paschou |
| Abstract |
Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co-occurrence of the two disorders suggests a shared genetic background. A major step toward the elucidation of the genetic architecture of TS was undertaken by the first TS Genome-wide Association Study (GWAS) reporting 552 SNPs that were moderately associated with TS (p < 1E-3). Similarly, initial ADHD GWAS attempts and meta-analysis were not able to produce genome-wide significant findings, but have provided insight to the genetic basis of the disorder. Here, we examine the common genetic background of the two neuropsychiatric phenotypes, by meta-analyzing the 552 top hits in the TS GWAS with the results of ADHD first GWASs. We identify 19 significant SNPs, with the top four implicated genes being TBC1D7, GUCY1A3, RAP1GDS1, and CHST11. TBCD17 harbors the top scoring SNP, rs1866863 (p:3.23E-07), located in a regulatory region downstream of the gene, and the third best-scoring SNP, rs2458304 (p:2.54E-06), located within an intron of the gene. Both variants were in linkage disequilibrium with eQTL rs499818, indicating a role in the expression levels of the gene. TBC1D7 is the third subunit of the TSC1/TSC2 complex, an inhibitor of the mTOR signaling pathway, with a central role in cell growth and autophagy. The top genes implicated by our study indicate a complex and intricate interplay between them, warranting further investigation into a possibly shared etiological mechanism for TS and ADHD. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 18% |
| United States | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 12 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 88% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 27% |
| Researcher | 7 | 13% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Professor | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 22% |
| Agricultural and Biological Sciences | 9 | 16% |
| Psychology | 8 | 15% |
| Medicine and Dentistry | 6 | 11% |
| Computer Science | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2020.
All research outputs
#3,020,681
of 25,374,647 outputs
Outputs from Frontiers in Neuroscience
#2,014
of 11,542 outputs
Outputs of similar age
#52,886
of 378,458 outputs
Outputs of similar age from Frontiers in Neuroscience
#36
of 154 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 378,458 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.