Title |
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control
|
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Published in |
Frontiers in Neuroscience, April 2017
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DOI | 10.3389/fnins.2017.00224 |
Pubmed ID | |
Authors |
Roberta Haddad-Tóvolli, Nathalia R. V. Dragano, Albina F. S. Ramalho, Licio A. Velloso |
Abstract |
Under physiological conditions, the brain consumes over 20% of the whole body energy supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries and the neuronal network in order to provide an adequate control of molecules that are transported in and out of the brain. Alterations in the BBB structure and function affecting brain accessibility to nutrients and exit of toxins are found in a number of diseases, which in turn may disturb brain function and nutrient signaling. In this review we explore the major advances obtained in the understanding of the BBB development and how its structure impacts on function. Furthermore, we focus on the particularities of the barrier permeability in the hypothalamus, its role in metabolic control and the potential impact of hypothalamic BBB abnormities in metabolic related diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
Unknown | 285 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 49 | 17% |
Student > Bachelor | 43 | 15% |
Student > Ph. D. Student | 38 | 13% |
Student > Master | 28 | 10% |
Student > Doctoral Student | 15 | 5% |
Other | 28 | 10% |
Unknown | 85 | 30% |
Readers by discipline | Count | As % |
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Neuroscience | 57 | 20% |
Biochemistry, Genetics and Molecular Biology | 37 | 13% |
Medicine and Dentistry | 26 | 9% |
Agricultural and Biological Sciences | 25 | 9% |
Engineering | 10 | 3% |
Other | 39 | 14% |
Unknown | 92 | 32% |