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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Exosomes as Carriers of Alzheimer's Amyloid-ß
|
|---|---|
| Published in |
Frontiers in Neuroscience, April 2017
|
| DOI | 10.3389/fnins.2017.00229 |
| Pubmed ID | |
| Authors |
Kohei Yuyama, Yasuyuki Igarashi |
| Abstract |
The intracerebral level of the aggregation-prone peptide, amyloid-ß (Aß), is constantly maintained by multiple clearance mechanisms, including several degradation enzymes, and brain efflux. Disruption of the clearance machinery and the resultant Aß accumulation gives rise to neurotoxic assemblies, leading to the pathogenesis of Alzheimer's disease (AD). In addition to the classic mechanisms of Aß clearance, the protein may be processed by secreted vesicles, although this possibility has not been extensively investigated. We showed that neuronal exosomes, a subtype of extracellular nanovesicles, enwrap, or trap Aß and transport it into microglia for degradation. Here, we review Aß sequestration and elimination by exosomes, and discuss how this clearance machinery might contribute to AD pathogenesis and how it might be exploited for effective AD therapy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Canada | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Peru | 1 | <1% |
| Unknown | 177 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 19% |
| Researcher | 26 | 15% |
| Student > Master | 24 | 13% |
| Student > Bachelor | 23 | 13% |
| Student > Doctoral Student | 11 | 6% |
| Other | 27 | 15% |
| Unknown | 34 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 19% |
| Neuroscience | 34 | 19% |
| Agricultural and Biological Sciences | 25 | 14% |
| Medicine and Dentistry | 14 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 6% |
| Other | 18 | 10% |
| Unknown | 42 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2017.
All research outputs
#3,344,339
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#2,533
of 11,542 outputs
Outputs of similar age
#58,085
of 323,623 outputs
Outputs of similar age from Frontiers in Neuroscience
#41
of 209 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 209 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.