Title |
Activation of Brain Somatostatin Signaling Suppresses CRF Receptor-Mediated Stress Response
|
---|---|
Published in |
Frontiers in Neuroscience, April 2017
|
DOI | 10.3389/fnins.2017.00231 |
Pubmed ID | |
Authors |
Andreas Stengel, Yvette F. Taché |
Abstract |
Corticotropin-releasing factor (CRF) is the hallmark brain peptide triggering the response to stress and mediates-in addition to the stimulation of the hypothalamus-pituitary-adrenal (HPA) axis-other hormonal, behavioral, autonomic and visceral components. Earlier reports indicate that somatostatin-28 injected intracerebroventricularly counteracts the acute stress-induced ACTH and catecholamine release. Mounting evidence now supports that activation of brain somatostatin signaling exerts a broader anti-stress effect by blunting the endocrine, autonomic, behavioral (with a focus on food intake) and visceral gastrointestinal motor responses through the involvement of distinct somatostatin receptor subtypes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | 2% |
Unknown | 55 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 9 | 16% |
Student > Doctoral Student | 7 | 13% |
Student > Postgraduate | 6 | 11% |
Researcher | 5 | 9% |
Other | 11 | 20% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
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Neuroscience | 16 | 29% |
Agricultural and Biological Sciences | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Medicine and Dentistry | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 6 | 11% |
Unknown | 13 | 23% |