You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension
|
|---|---|
| Published in |
Frontiers in Neuroscience, April 2017
|
| DOI | 10.3389/fnins.2017.00235 |
| Pubmed ID | |
| Authors |
Manuel Vidal-Sanz, Caridad Galindo-Romero, Francisco J. Valiente-Soriano, Francisco M. Nadal-Nicolás, Arturo Ortin-Martinez, Giuseppe Rovere, Manuel Salinas-Navarro, Fernando Lucas-Ruiz, Maria C. Sanchez-Migallon, Paloma Sobrado-Calvo, Marcelino Aviles-Trigueros, María P. Villegas-Pérez, Marta Agudo-Barriuso |
| Abstract |
Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve head plays a major role. Rodent models to study glaucoma include those that mimic either ocular hypertension or optic nerve injury. Here we review the anatomical loss of the general population of RGCs (that express Brn3a; Brn3a(+)RGCs) and of the intrinsically photosensitive RGCs (that express melanopsin; m(+)RGCs) after chronic (LP-OHT) or acute (A-OHT) ocular hypertension and after complete intraorbital optic nerve transection (ONT) or crush (ONC). Our studies show that all of these insults trigger RGC death. Compared to Brn3a(+)RGCs, m(+)RGCs are more resilient to ONT, ONC, and A-OHT but not to LP-OHT. There are differences in the course of RGC loss both between these RGC types and among injuries. An important difference between the damage caused by ocular hypertension or optic nerve injury appears in the outer retina. Both axotomy and LP-OHT induce selective loss of RGCs but LP-OHT also induces a protracted loss of cone photoreceptors. This review outlines our current understanding of the anatomical changes occurring in rodent models of glaucoma and discusses the advantages of each one and their translational value. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 26% |
| Student > Master | 7 | 12% |
| Student > Bachelor | 7 | 12% |
| Student > Doctoral Student | 3 | 5% |
| Other | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 13 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 25% |
| Biochemistry, Genetics and Molecular Biology | 10 | 18% |
| Medicine and Dentistry | 8 | 14% |
| Agricultural and Biological Sciences | 7 | 12% |
| Unspecified | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 13 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#7,427
of 11,542 outputs
Outputs of similar age
#195,410
of 323,575 outputs
Outputs of similar age from Frontiers in Neuroscience
#138
of 209 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,575 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 209 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.