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Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates

Overview of attention for article published in Frontiers in Neuroscience, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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1 news outlet
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2 X users

Citations

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18 Dimensions

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36 Mendeley
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Title
Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates
Published in
Frontiers in Neuroscience, May 2017
DOI 10.3389/fnins.2017.00277
Pubmed ID
Authors

Vladimir F. Lazarev, Elena R. Mikhaylova, Irina V. Guzhova, Boris A. Margulis

Abstract

The vast majority of neurodegenerative pathologies stem from the formation of toxic oligomers and aggregates composed of wrongly folded proteins. These protein complexes can be released from pathogenic cells and enthralled by other cells, causing the formation of new aggregates in a prion-like manner. By this mechanism, migrating complexes can transmit a disorder to distant regions of the brain and promote gradually transmitting degenerative processes. Molecular chaperones can counteract the toxicity of misfolded proteins. In this review, we discuss recent data on the possible cytoprotective functions of chaperones in horizontally transmitting neurological disorders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 22%
Student > Ph. D. Student 6 17%
Student > Master 5 14%
Professor 4 11%
Researcher 3 8%
Other 5 14%
Unknown 5 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 31%
Agricultural and Biological Sciences 7 19%
Neuroscience 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Medicine and Dentistry 2 6%
Other 3 8%
Unknown 7 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2017.
All research outputs
#3,562,512
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#2,876
of 11,542 outputs
Outputs of similar age
#61,614
of 325,242 outputs
Outputs of similar age from Frontiers in Neuroscience
#39
of 204 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.