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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
|
|---|---|
| Published in |
Frontiers in Neuroscience, May 2017
|
| DOI | 10.3389/fnins.2017.00278 |
| Pubmed ID | |
| Authors |
Maja Mustapic, Erez Eitan, John K. Werner, Sean T. Berkowitz, Michael P. Lazaropoulos, Joyce Tran, Edward J. Goetzl, Dimitrios Kapogiannis |
| Abstract |
Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegenerative diseases in multiple studies, providing a strong proof of concept for this approach. Here, we describe our methodology in detail and offer further evidence that isolated EVs are enriched for neuronal origin. In addition, we present evidence that EVs enriched for neuronal origin represent a more sensitive and accurate base for biomarkers than plasma, serum, or non-enriched total plasma EVs. Finally, we proceed to investigate the protein content of EVs enriched for neuronal origin and compare it with other relevant enriched and non-enriched populations of plasma EVs. Neuronal-origin enriched plasma EVs contain higher levels of signaling molecules of great interest for cellular metabolism, survival, and repair, which may be useful as biomarkers and to follow response to therapeutic interventions in a mechanism-specific manner. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Nigeria | 4 | 11% |
| United States | 3 | 8% |
| Switzerland | 2 | 5% |
| Ecuador | 1 | 3% |
| Brazil | 1 | 3% |
| Malaysia | 1 | 3% |
| Chile | 1 | 3% |
| Italy | 1 | 3% |
| Mexico | 1 | 3% |
| Other | 5 | 14% |
| Unknown | 17 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 78% |
| Scientists | 7 | 19% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 385 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 385 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 80 | 21% |
| Student > Ph. D. Student | 52 | 14% |
| Student > Bachelor | 32 | 8% |
| Student > Master | 31 | 8% |
| Other | 22 | 6% |
| Other | 52 | 14% |
| Unknown | 116 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 65 | 17% |
| Neuroscience | 61 | 16% |
| Agricultural and Biological Sciences | 38 | 10% |
| Medicine and Dentistry | 30 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 4% |
| Other | 40 | 10% |
| Unknown | 136 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2019.
All research outputs
#1,263,336
of 25,562,515 outputs
Outputs from Frontiers in Neuroscience
#564
of 11,619 outputs
Outputs of similar age
#24,573
of 327,777 outputs
Outputs of similar age from Frontiers in Neuroscience
#11
of 186 outputs
Altmetric has tracked 25,562,515 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,619 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,777 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.