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Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus

Overview of attention for article published in Frontiers in Neuroscience, July 2017
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Title
Weaker Functional Connectivity Strength in Patients with Type 2 Diabetes Mellitus
Published in
Frontiers in Neuroscience, July 2017
DOI 10.3389/fnins.2017.00390
Pubmed ID
Authors

Linlin Liu, Wanhu Li, Yang Zhang, Wen Qin, Shan Lu, Quan Zhang

Abstract

Type 2 diabetes mellitus (T2DM) is related to cognitive impairments and increased risk for dementia. Neuroimaging studies have demonstrated T2DM-related brain structural and functional changes which are partly associated to the cognitive decline. However, few studies focused on the early neuroimaging findingsin T2DM patients. In this study, a data-driven whole-brain resting state functional connectivity strength (rsFCS) methodwas used to evaluate resting functional changes in 53 T2DM patients compared with 55 matched healthy controls (HCs), and to detect the associations between the rsFCSchanges and cognitive functions in T2DM patients. The T2DM patients exhibited weaker long-range rsFCS in the right insula and weaker short-range rsFCS in the right supramarginalgyrus (SG) compared with the HCs. Additionally, seed-based functional connectivity (FC) analysis revealed weaker FC between the right insula and the bilateral superior parietal lobule (SPL), and between the right SG and the bilateral supplementary motor area (SMA)/right SPL in T2DM patientscompared with the HCs. In T2DM patients, negative correlation was found between the long-range rsFCS in the right insula and HbA1c levels; and the FC between the right SG and the bilateral SMA negatively correlated with TMT-A scores. Our results indicated that the rsFCS alteration occurredbefore obvious cognitive deficits in T2DM patients, which might be helpful for understanding the neuromechanism of cognitive declines in T2DM patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 16%
Student > Bachelor 6 16%
Professor 5 13%
Student > Ph. D. Student 4 11%
Lecturer 3 8%
Other 5 13%
Unknown 9 24%
Readers by discipline Count As %
Psychology 6 16%
Medicine and Dentistry 5 13%
Neuroscience 4 11%
Computer Science 3 8%
Nursing and Health Professions 2 5%
Other 7 18%
Unknown 11 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#8,671
of 11,542 outputs
Outputs of similar age
#236,453
of 325,442 outputs
Outputs of similar age from Frontiers in Neuroscience
#140
of 178 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
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