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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
|
|---|---|
| Published in |
Frontiers in Neuroscience, December 2017
|
| DOI | 10.3389/fnins.2017.00680 |
| Pubmed ID | |
| Authors |
Kevin A. Clayton, Alicia A. Van Enoo, Tsuneya Ikezu |
| Abstract |
Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully understood. Alzheimer's disease is the most common proteopathy and is characterized by two unique pathologies: senile plaques and neurofibrillary tangles, the former accumulating earlier than the latter. Aging alters the proteostasis of amyloid-β peptides and microtubule-associated protein tau, which are regulated in both autonomous and non-autonomous manners. Microglia, the resident phagocytes of the central nervous system, play a major role in the non-autonomous clearance of protein aggregates. Their function is significantly altered by aging and neurodegeneration. This is genetically supported by the association of microglia-specific genes, TREM2 and CD33, and late onset Alzheimer's disease. Here, we propose that the functional characterization of microglia, and their contribution to proteopathy, will lead to a new therapeutic direction in Alzheimer's disease research. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 276 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 276 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 21% |
| Student > Bachelor | 49 | 18% |
| Researcher | 42 | 15% |
| Student > Master | 26 | 9% |
| Student > Doctoral Student | 13 | 5% |
| Other | 33 | 12% |
| Unknown | 56 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 52 | 19% |
| Biochemistry, Genetics and Molecular Biology | 42 | 15% |
| Agricultural and Biological Sciences | 36 | 13% |
| Medicine and Dentistry | 36 | 13% |
| Immunology and Microbiology | 11 | 4% |
| Other | 27 | 10% |
| Unknown | 72 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2022.
All research outputs
#14,920,631
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#6,088
of 11,542 outputs
Outputs of similar age
#224,655
of 443,738 outputs
Outputs of similar age from Frontiers in Neuroscience
#105
of 187 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,738 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.