Title |
ER Dynamics and Derangement in Neurological Diseases
|
---|---|
Published in |
Frontiers in Neuroscience, February 2018
|
DOI | 10.3389/fnins.2018.00091 |
Pubmed ID | |
Authors |
Tomoyuki Yamanaka, Nobuyuki Nukina |
Abstract |
The endoplasmic reticulum (ER) is a morphologically dynamic organelle containing different membrane subdomains with distinct cellular functions. Numerous observations have revealed that ER stress response induced by disturbed ER homeostasis is linked to various neurological/neurodegenerative disorders. In contrast, recent findings unveil that ER structural derangements are linked to the progression of several neurological diseases. The derangements involve two distinct, and likely opposing pathways. One is dysfunction of ER dynamics machinery, leading to disruption of ER network organization. Another one is facilitation of pre-existing machinery, leading to generation of markedly-orderedde novomembranous structure. Restoring the ER network can be the effective way toward the cure of ER-deranged neurological disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 14% |
France | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 27% |
Student > Bachelor | 10 | 16% |
Researcher | 6 | 10% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 2 | 3% |
Other | 7 | 11% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 18 | 29% |
Agricultural and Biological Sciences | 8 | 13% |
Neuroscience | 7 | 11% |
Medicine and Dentistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 11% |
Unknown | 18 | 29% |