Title |
Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use
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Published in |
Frontiers in Neuroscience, April 2018
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DOI | 10.3389/fnins.2018.00239 |
Pubmed ID | |
Authors |
Helge H. O. Müller, Sebastian Moeller, Caroline Lücke, Alexandra P. Lam, Niclas Braun, Alexandra Philipsen |
Abstract |
In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 2 | 20% |
United States | 1 | 10% |
Canada | 1 | 10% |
France | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 127 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 23 | 18% |
Student > Bachelor | 14 | 11% |
Researcher | 10 | 8% |
Student > Ph. D. Student | 9 | 7% |
Student > Doctoral Student | 7 | 6% |
Other | 18 | 14% |
Unknown | 46 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 13% |
Psychology | 17 | 13% |
Neuroscience | 15 | 12% |
Engineering | 7 | 6% |
Nursing and Health Professions | 6 | 5% |
Other | 13 | 10% |
Unknown | 52 | 41% |