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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease
|
|---|---|
| Published in |
Frontiers in Neuroscience, April 2018
|
| DOI | 10.3389/fnins.2018.00254 |
| Pubmed ID | |
| Authors |
Isabelle L. Sumner, Ross A. Edwards, Ayodeji A. Asuni, Jessica L. Teeling |
| Abstract |
There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by deposits of Amyloid-β (Aβ), neurofibrillary tangles, and neuroinflammation, and several drug discovery programmes studies have focussed on Aβ as therapeutic target. Active immunization and passive immunization against Aβ leads to the clearance of deposits in humans and transgenic mice expressing human Aβ but have failed to improve memory loss. This review will discuss the possible explanations for the lack of efficacy of Aβ immunotherapy, including the role of a pro-inflammatory response and subsequent vascular side effects, the binding site of therapeutic antibodies and the timing of the treatment. We further discuss how antibodies can be engineered for improved efficacy. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 38% |
| Netherlands | 1 | 8% |
| Switzerland | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 17% |
| Student > Ph. D. Student | 11 | 13% |
| Researcher | 8 | 10% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 6 | 7% |
| Unknown | 32 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 11% |
| Medicine and Dentistry | 9 | 11% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 4 | 5% |
| Unknown | 36 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2022.
All research outputs
#2,008,063
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#1,108
of 11,542 outputs
Outputs of similar age
#41,774
of 340,059 outputs
Outputs of similar age from Frontiers in Neuroscience
#33
of 241 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,059 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.