Title |
Association Between Autophagy and Neurodegenerative Diseases
|
---|---|
Published in |
Frontiers in Neuroscience, May 2018
|
DOI | 10.3389/fnins.2018.00255 |
Pubmed ID | |
Authors |
Nobuhiro Fujikake, Minkyoung Shin, Shigeomi Shimizu |
Abstract |
Autophagy is a phylogenetically conserved mechanism that controls the degradation of subcellular constituents, including misfolded proteins, and damaged organelles. The progression of many neurodegenerative diseases is thought to be driven by the aggregation of misfolded proteins; therefore, autophagic activity is thought to affect disease severity to some extent. In some neurodegenerative diseases, the suppression of autophagic activity accelerates disease progression. Given that the induction of autophagy can potentially mitigate disease severity, various autophagy-inducing compounds have been developed and their efficacy has been evaluated in several rodent models of neurodegenerative diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 13% |
United Kingdom | 2 | 13% |
France | 1 | 6% |
Switzerland | 1 | 6% |
Unknown | 10 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 88% |
Scientists | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 187 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 19% |
Researcher | 28 | 15% |
Student > Master | 24 | 13% |
Student > Bachelor | 18 | 10% |
Student > Postgraduate | 8 | 4% |
Other | 21 | 11% |
Unknown | 52 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 24% |
Neuroscience | 32 | 17% |
Agricultural and Biological Sciences | 18 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 7% |
Medicine and Dentistry | 11 | 6% |
Other | 12 | 6% |
Unknown | 56 | 30% |