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Reduced Cyclic Adenosine Monophosphate Level in Hippocampal CA1 Participates in Propofol Induced Amnesia in Rats

Overview of attention for article published in Frontiers in Neuroscience, May 2018
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Title
Reduced Cyclic Adenosine Monophosphate Level in Hippocampal CA1 Participates in Propofol Induced Amnesia in Rats
Published in
Frontiers in Neuroscience, May 2018
DOI 10.3389/fnins.2018.00337
Pubmed ID
Authors

Weiwei Li, Lingling Yu, Xiaodi Yan, Linlin Cai, Li Wan, Qinyu Teng, Yonghua Li, Yun Wang, Haitao Xu

Abstract

Propofol inhibits long-term potentiation (LTP) in the hippocampal CA1 region and impedes episodic memory formation. However, the molecular mechanisms involved in the effect of propofol are still poorly understood. It had been reported that propofol inhibited cAMP response element binding protein signaling, which was proposed to contribute to memory retention impairment in rats. Here, we first demonstrated that propofol perfusion could inhibit forskolin induced LTP in the rat hippocampal CA1 slices. Propofol also reduced the level of cAMP, which could be reversed by non-selective PDE inhibitor IBMX. We further discovered that propofol could increase both PDE4 activity and PDE4AX protein expressions in the hippocampal CA1 region. Furthermore, pretreatment of rolipram, a PDE4 inhibitor, rescued propofol induced inhibition of CA1 LTP and the impairment of hippocampus-dependent memory formation in rats. Thus, our results suggest that reduced levels of cAMP by increasing PDE4 activity and PDE4AX protein expressions in the hippocampal CA1 region plays an important role in the propofol-induced amnesia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 45%
Student > Ph. D. Student 2 18%
Unspecified 1 9%
Lecturer 1 9%
Student > Doctoral Student 1 9%
Other 0 0%
Unknown 1 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 18%
Medicine and Dentistry 2 18%
Neuroscience 2 18%
Agricultural and Biological Sciences 1 9%
Unspecified 1 9%
Other 2 18%
Unknown 1 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#22,767,715
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#10,138
of 11,542 outputs
Outputs of similar age
#302,085
of 343,952 outputs
Outputs of similar age from Frontiers in Neuroscience
#236
of 243 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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