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Epigenetic and Transcriptional Pre-patterning—An Emerging Theme in Cortical Neurogenesis

Overview of attention for article published in Frontiers in Neuroscience, May 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Title
Epigenetic and Transcriptional Pre-patterning—An Emerging Theme in Cortical Neurogenesis
Published in
Frontiers in Neuroscience, May 2018
DOI 10.3389/fnins.2018.00359
Pubmed ID
Authors

Mareike Albert, Wieland B. Huttner

Abstract

Neurogenesis is the process through which neural stem and progenitor cells generate neurons. During the development of the mouse neocortex, stem and progenitor cells sequentially give rise to neurons destined to different cortical layers and then switch to gliogenesis resulting in the generation of astrocytes and oligodendrocytes. Precise spatial and temporal regulation of neural progenitor differentiation is key for the proper formation of the complex structure of the neocortex. Dynamic changes in gene expression underlie the coordinated differentiation program, which enables the cells to generate the RNAs and proteins required at different stages of neurogenesis and across different cell types. Here, we review the contribution of epigenetic mechanisms, with a focus on Polycomb proteins, to the regulation of gene expression programs during mouse neocortical development. Moreover, we discuss the recent emerging concept of epigenetic and transcriptional pre-patterning in neocortical progenitor cells as well as post-transcriptional mechanisms for the fine-tuning of mRNA abundance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 90 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 22%
Researcher 13 14%
Student > Bachelor 11 12%
Student > Master 7 8%
Other 4 4%
Other 11 12%
Unknown 24 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 24%
Neuroscience 18 20%
Agricultural and Biological Sciences 14 16%
Unspecified 2 2%
Environmental Science 1 1%
Other 6 7%
Unknown 27 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2023.
All research outputs
#4,281,274
of 25,382,440 outputs
Outputs from Frontiers in Neuroscience
#3,490
of 11,542 outputs
Outputs of similar age
#78,047
of 344,685 outputs
Outputs of similar age from Frontiers in Neuroscience
#76
of 234 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,542 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 234 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.