Title |
BCI Performance and Brain Metabolism Profile in Severely Brain-Injured Patients Without Response to Command at Bedside
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Published in |
Frontiers in Neuroscience, June 2018
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DOI | 10.3389/fnins.2018.00370 |
Pubmed ID | |
Authors |
Jitka Annen, Séverine Blandiaux, Nicolas Lejeune, Mohamed A. Bahri, Aurore Thibaut, Woosang Cho, Christoph Guger, Camille Chatelle, Steven Laureys |
Abstract |
Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish "covert command following." These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed "covert command following" (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without "covert command-following" but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe "covert command following" in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC. |
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Switzerland | 2 | 50% |
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Scientists | 1 | 25% |
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Researcher | 6 | 16% |
Student > Master | 5 | 14% |
Student > Bachelor | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
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Other | 5 | 14% |
Unknown | 5 | 14% |