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Mendeley readers
Attention Score in Context
| Title |
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
|
|---|---|
| Published in |
Frontiers in Neuroscience, September 2021
|
| DOI | 10.3389/fnins.2021.742065 |
| Pubmed ID | |
| Authors |
Luca Muzio, Alice Viotti, Gianvito Martino |
| Abstract |
Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris. Microglia emerge from early erythromyeloid progenitors of the yolk sac and enter the developing brain before the establishment of a fully mature blood-brain barrier. In physiological conditions, during brain development, microglia contribute to CNS homeostasis by supporting cell proliferation of neural precursors. In post-natal life, such cells contribute to preserving the integrity of neuronal circuits by sculpting synapses. After a CNS injury, microglia change their morphology and down-regulate those genes supporting homeostatic functions. However, it is still unclear whether such changes are accompanied by molecular and functional modifications that might contribute to the pathological process. While comprehensive transcriptome analyses at the single-cell level have identified specific gene perturbations occurring in the "pathological" microglia, still the precise protective/detrimental role of microglia in neurological disorders is far from being fully elucidated. In this review, the results so far obtained regarding the role of microglia in neurodegenerative disorders will be discussed. There is solid and sound evidence suggesting that regulating microglia functions during disease pathology might represent a strategy to develop future therapies aimed at counteracting brain degeneration in multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 335 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 335 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 11% |
| Student > Bachelor | 34 | 10% |
| Researcher | 30 | 9% |
| Student > Master | 26 | 8% |
| Student > Doctoral Student | 13 | 4% |
| Other | 53 | 16% |
| Unknown | 142 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 54 | 16% |
| Biochemistry, Genetics and Molecular Biology | 46 | 14% |
| Medicine and Dentistry | 17 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 5% |
| Agricultural and Biological Sciences | 14 | 4% |
| Other | 32 | 10% |
| Unknown | 156 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2023.
All research outputs
#1,791,133
of 25,392,582 outputs
Outputs from Frontiers in Neuroscience
#937
of 11,543 outputs
Outputs of similar age
#41,092
of 435,241 outputs
Outputs of similar age from Frontiers in Neuroscience
#26
of 410 outputs
Altmetric has tracked 25,392,582 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 435,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 410 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.