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Attention Score in Context
| Title |
Neuronal influence behind the central nervous system regulation of the immune cells
|
|---|---|
| Published in |
Frontiers in Integrative Neuroscience, January 2013
|
| DOI | 10.3389/fnint.2013.00064 |
| Pubmed ID | |
| Authors |
Anahí Chavarría, Graciela Cárdenas |
| Abstract |
Central nervous system (CNS) has a highly specialized microenvironment, and despite being initially considered an immune privileged site, this immune status is far from absolute because it varies with age and brain topography. The brain monitors immune responses by several means that act in parallel; one pathway involves afferent nerves (vagal nerve) and the other resident cells (neurons and glia). These cell populations exert a strong role in the regulation of the immune system, favoring an immune-modulatory environment in the CNS. Neurons control glial cell and infiltrated T-cells by contact-dependent and -independent mechanisms. Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5, and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells. On the other hand, soluble neuronal factors like Sema-3A, cytokines, neurotrophins, neuropeptides, and neurotransmitters attenuate microglial and/or T-cell activation. In this review, we focused on all known mechanism driven only by neurons in order to control the local immune cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Ireland | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 103 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 30% |
| Student > Bachelor | 16 | 15% |
| Researcher | 13 | 12% |
| Student > Master | 10 | 9% |
| Student > Postgraduate | 6 | 6% |
| Other | 16 | 15% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 36% |
| Neuroscience | 16 | 15% |
| Medicine and Dentistry | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 10 | 9% |
| Immunology and Microbiology | 7 | 7% |
| Other | 8 | 7% |
| Unknown | 14 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2013.
All research outputs
#17,695,202
of 22,719,618 outputs
Outputs from Frontiers in Integrative Neuroscience
#644
of 853 outputs
Outputs of similar age
#210,203
of 280,759 outputs
Outputs of similar age from Frontiers in Integrative Neuroscience
#75
of 89 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 853 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,759 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.